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Too many fertility patients are told they have premature ovarian failure (POF) when they only have premature ovarian aging (POA). A New York fertility center points out that with POA, women can often get pregnant without donor eggs, while women with premature ovarian failure (premature menopause) usually need egg donation.
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June 14, 2011 (New York, NY) - Infertile women all over the world are falling victim to a widespread misunderstanding of premature ovarian failure (POF), a medical condition in which a woman's ovarian function is lost prematurely ,warns a New York fertility expert. This misunderstanding, in some cases, results in women resorting to egg donation, even when they still have a decent chance of pregnancy without donor eggs.
Premature ovarian failure (POF) is also called premature menopause or primary ovarian insufficiency (POI), a recently coined medical terminology. Current diagnostic criteria for POF are follicle stimulating hormone (FSH) level above 40.0 mIU/mL before age 40, a condition known as high FSH. True POF affects only approximately 1% of all women. However, approximately 10% of all women experience premature declines of ovarian function, which are milder than outright POF. This milder decline in ovarian function is called premature ovarian aging (POA) or occult primary ovarian insufficiency (OPOI).
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This multitude of medical terminologies for similar or identical medical conditions has led to serious problems for affected patients. 'Correct diagnosis is crucial in advising patients about prognosis and treatment choices, because women with POA, especially if under age 42, still have excellent pregnancy chances with correct treatments,' explains Norbert Gleicher, MD, Founder and Medical Director of the Center for Human Reproduction (CHR) in New York City. 'In contrast, women with true POF have much poorer pregnancy chances with the use of their own eggs, and usually require experimental treatments.'
While women with POF and POA represent only a small minority of all women, they are a significant presence in infertility setting. 'The percentages amongst patients vary between fertility centers, but have been reported to reach 50-60% in centers like CHR that specialize in women with diminished ovarian function,' notes David H Barad, MD, MS, the center's Clinical Director of Assisted Reproduction. 'Incorrect diagnoses and treatments can, therefore, negatively affect a rather large number of infertility patients.'
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'We see an increasing number of POA patients who have been given a POF diagnosis,' adds Dr. Gleicher. 'They are advised to pursue egg donation very prematurely, in our opinion. A significant minority of those who consult our center after such advice end up conceiving without egg donation!'
CHR is a leading infertility center in New York City, with world-wide patient clientele, well recognized for its extensive clinical research program, which over the years contributed a number of major breakthrough to the IVF process. Dr. Gleicher is available for additional comments.
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Norbert Gleicher, MD, FACOG, FACS
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Norbert Gleicher, MD, leads CHR’s clinical and research efforts as Medical Director and Chief Scientist. A world-renowned specialist in reproductive endocrinology, Dr. Gleicher has published hundreds of peer-reviewed papers and lectured globally while keeping an active clinical career focused on ovarian aging, immunological issues and other difficult cases of infertility.
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